Multivalent fusion protein vaccine for lymphatic filariasis
نویسندگان
چکیده
منابع مشابه
Evaluation of a Multivalent Vaccine against Lymphatic Filariasis in Rhesus macaque Model
Lymphatic filariasis affects 120 million people worldwide and another 1.2 billion people are at risk of acquiring the infection. Chemotherapy with mass drug administration is substantially reducing the incidence of the infection. Nevertheless, an effective vaccine is needed to prevent the infection and eradicate the disease. Previously we reported that a multivalent fusion protein vaccine (rBmH...
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As an alternative brucellosis prevention method, we evaluated the immunogenicity induced by new multivalent DNA vaccines in BALB/c mice. We constructed the vaccines by fusion of BAB1_0273 and/or BAB1_0278 open reading frames (ORFs) from genomic island 3 (GI-3) and the Brucella abortus 2308 sodC gene with a link based on prolines and alanines (pV273-sod, pV278-sod, and pV273-278-sod, resp.). Res...
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In 2000, annual mass administration of diethlycarbamazine and albendazole began in Leogane Commune, Haiti, to interrupt transmission of lymphatic filariasis (LF). After 5 years of treatment, microfilaremia, antigenemia, and mosquito infection rates were significantly reduced, but LF transmission was not interrupted. These finding have implications for other LF elimination programs.
متن کاملLymphatic Filariasis: An Overview
Wuchereria brancofti, Brugia malayi, Brugia timori are the main parasites which causes lymphatic filariasis. Lymphatic filariasis is a neglected topical disease with more than 1.3 billoin people worldwide. These are spread from by blood-feeding black flies and mosquitoes. These worms occupy the lymphatic system, including the lymph nodes; in chronic cases, these worms lead to the disease elepha...
متن کاملMDA—Lymphatic Filariasis
Lymphatic filariasis is one of the neglected tropical diseases. It is estimated that 120 million people are currently infected in 73 countries where filariasis is endemic. Lymphatic filariasis is a leading cause of chronic disability worldwide, including of 15 million people who have lymphoedema (elephantiasis) and 25 million men who have hydrocoele.
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ژورنال
عنوان ژورنال: Vaccine
سال: 2013
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2012.09.055